DOSY

We can run the DOSY experiment at IU. This is the pseudo 2D diffusion correlated experiment giving 1D spectra on one axis (typically 1H) and self diffusion coefficient on the other. The major application is effectively separating proton spectra of mixture components by molecular size.

DOSY Example

To acquire DOSY data the gradient strength in a 1D PFGSE diffusion experiment is arrayed. We have the current best pulse sequences, DgsteSL_cc and Doneshot.

The key to DOSY is processing. Mestrenova includes novel DOSY processing that works well, Mnova DOSY, or you can use the free DOSY Toolbox that contains the better known methods.

A related 1D diffusion guide is at the bottom of: IU Training/Guides

See Doug for more info.

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